Two years field study was carried out at D block research farm of B.C.K.V Kalyani, to evaluate the bio-efficacy of Oxyfluorfen 23.5% EC to control weeds in potato during the Rabi seasons of 2016 - 2018. The experiment was carried out in a Randomized Block Design with four replications i.e, T1- Oxyfluorfen 23.5% EC @ 425 ml ha-1, T2- Oxyfluorfen 23.5% EC @ 625 ml ha-1, T3 - Oxyfluorfen 23.5% EC @ 850 ml ha-1, T4- Metribuzin 70% WP @ 0.75 kg ha-1, T5- straw mulch, T6- Two hand weedings at 20 and 40 days after sowing (Weed free check), T7 -Untreated control (weedy check). From the experiment, it is concluded that among different treatments, hand weeding at 20 and 40 days after crop sowing (T6), maintained its superiority with highest control of weeds and crop yield (25.80 t ha-1).All the herbicides had been applied as pre-emergence. Among herbicidal treatments, Oxyfluorfen 23.5% EC @ 850 ml ha-1 showed higher efficiency in controlling weeds with respect to number and dry weight of weeds after weed free check system. Based on the studies, the use of Oxyfluorfen 23.5% EC @ 850 ml ha-1 can be suggested for the control of weeds in potato crop.