A study was carried out at the AICRP potato experimental plots at OUAT, Bhubaneswar during the rabi seasons of 2018–19 and 2019–20 to assess the effectiveness of pesticides against potato aphid infestations and their impact on natural enemies. For the experiment, the untreated control, imidacloprid 17.8SL @ 0.4 ml l-1 of water seed treatment followed by sprays of imidacloprid 17.8SL @150ml ha^-1 and thiamethoxam 25WG @100 g ha^-1 at 30 and 40 days after planting (DAP), foliar spray of diafenthiuron 50WP @700gha^-1 once at 30 DAP, spray of diafenthiuron 50 at 30 and 40 DAP, foliar spray of castor oil @250 ml ha_-1, foliar spray of diafenthiuron 50WP @ 700g ha^-1 mixed with castor oil @250ml ha^-1at 30 DAP, and the same along with diafenthiuron 50WP @700g ha^-1 at 40 DAP were considered. The treatment consisting spray of diafenthiuron 50WP @700g ha^-1 mixed with castor oil @250ml ha^-1 at 30DAP followed by diafenthiuron 50WP @700g ha^-1 at 40DAP proved to be the most effective, with highest reduction in aphids. The diafenthiuron-containing treatments were proven comparatively safer for coccinellid predators.